Episode 1

When Izzie's new school club is a bust, she seeks help from the SciGirls. They teach her about evaluating habitats for turtles and she adapts the information to make her club more appealing.

Episode 2

Jake convinces Izzie that if she wants to become class President, she has to be taller. To accomplish this she looks to a group of SciGirls for inspiration as they create massive sized May Day Parade puppets with elaborate features.

Episode 3

Izzie finds herself unable to figure out Jake when he loses his voice. She turns to a pair of Scigirls who are observing and researching dolphin behavior, in the hopes of learning a new way to understand Jake by using the scigirls help

Episode 4

When Jake's lucky socks go missing before his science test, Izzie goes to the SciGirls for help! Their investigations into Native American archaeology inspire her to treat Jake's messy locker like a dig site.

Episode 5

The Sadie Hawkins dance is approaching and Izzie has to choose between two potential dates. She decides to model her selection process upon a series of SciGirls experiments designed to select the most ideal horse for an upcoming competition.

Episode 6

Concerned about the Earth's limited resources, when Izzie's laptop runs out of power she and the SciGirls investigate alternative power sources.

Episode 7

Izzie makes preparations for a triathlon, but realizes she isn't able to wear all athletic gear at the same time. Turning to the SciGirls, she learns how fashion and technology can be merged.

Episode 8

Jake loves eating snack food rather than terrible tasting healthy food, much to Izzie's concern. Luckily she finds four SciGirls who are out to remake their favorite meals into healthier, appetizing versions for their families.

Episode 9

Izzie is confused when she is described as the Most Unique Dresser at school. To find out if she's being complimented or not she compares notes with two SciGirls studying biodiversity.

Episode 10

Jake and Izzie attempt to catch Fang, his escaped pet mouse, with the aid of a remote controlled car with a camera. Fang bolts whenever the vehicle approaches, so they learn from a group of SciGirls how to make robots with better communicative skills.

Episode 11

After going through a huge amount Mighty Munchies containers, Jake and Izzie realize they have to take care of the mess. She follows three SciGirls who are designing new ways to reuse and recycle materials from their school's trash.

Episode 12

In a bid to help Jake distract a group of Talent Show judges with flashy lights, she tags along with a pair of SciGirls as they research light pollution.