Sheena's parents were archaeologists who died in the jungle when she was about six years old, leaving their daughter Shirley Hamilton. She was taken in by Kali, a local Shamaness of a tribe who brought her up, and five years ago she was taught how to morph into animals and birds, acquiring their abilities, even flight. Further, she became a mythical creature called "The Darachna" who relies on people' fear of the unknown. For this she covers herself in a dark liquid mud which allows her to be largely unseen in the low light of the jungle, and with more than normal strength, agility and speed, and armed with a pair of gloves with bone claws, she is a formidable one woman fighting force. She does kill sometimes.
Episode 1
Sheena and Cutter meet for the first time in a most unusual way after Sheena sabotages Cutter's plane and it crashes down into the jungle.
Episode 2
After a U.S. defense department satellite crashes into the jungle, it's up to Sheena, Cutter and Cutter's old nemesis, Tyler, to track down and deprogram the satellite before the area is bombed by the military.
Episode 3
The cargo of coffee that Cutter was hired to deliver turns out to be a shipment of smuggled animals from the jungle known as Jirds.
Episode 4
A group of rogue gorillas terrorize villages throughout the jungle. As Sheena prepares to fight them off she discovers a secret Kali has been hiding. Consequently, Sheena must choose between her friend and the safety of her village.
Episode 5
Cutter takes a group of tourists for the ride of their lives when they run into and are captured by a band of virus smugglers.
Episode 6
A volcano in the LaMistas is causing seismic earthquakes. While rescuing animals from danger, Sheena finds an old stachel buried in the ground that triggers memories of her parents¹ death.
Episode 7
When an evil corporation tries to steal the land of the peaceful Souman tribe, Sheena helps them fight back.
Episode 8
Sheena is trapped in a half-animal state and it's up to Cutter to find her before an obsessed trophy hunter gets to her first.
Episode 9
When N'Gama's troops kidnap a young woman from Kali's village for him to marry, Sheena must don western clothing and infiltrate N'Gama's palace to rescue the girl.
Episode 10
Sheena comes face to face with an old enemy. As she plans her revenge, she finds an old friend in trouble and uncovers a bizarre experiment.
Episode 11
When Sheena enlists Cutter's help to stop the illegal rare game hunt, she finds that the animals aren't the only ones being pursued.
Episode 12
Cutter is in heaven when some supermodels need his guidance through the jungle for a photo shoot. But when the photographer turns the shoot into a rescue operation, not everyone is who they seem to be.
Episode 13
Sheena and Cutter, on a search for two missing botanists in a remote and highly dangerous part of the LaMistas, find a very hostile environment with a secret that could pit them against each other in a fight to the death.
Episode 14
When a well-known TV icon captures footage of the Darak'Na for his show, sparking a tribal war, it's up to Sheena to keep the peace, and her secret, intact.
Episode 15
A civil war breaks out in Kamdeera when a rebel army takes over part of the country. Sheena and Cutter are caught in the middle, between rescuing refugees trapped in a sanctuary and helping a small force of UN soldiers, cut off from back-up battle the rebels. The situation looks bleak, but Sheena's got plans of her own.
Episode 16
Sheena steals Cutter's prized signed footballs to coerce him into helping her find the Kamada tribe's sacred jewel.
Episode 17
Sheena's old friend, Tuli, returns to the LaMistas in search of a plant that may cure radiation poisoning. But when Tuli is gravely injured by her cutthroat rival, Sheena is compelled to put aside her resentment and save her friend's life.
Episode 18
When Tuma, the leader of the Kiptalamis, attacks a peaceful meeting between the leaders of the four tribes, Sheena discovers that he wants sole ownership of a sacred rock shared by the tribes and will kill any one who gets in the way of his destiny.
Episode 19
When a young friend of Sheena's is killed in a bombing, Cutter's old friend Tyler reappears to lead a mission to assassinate the terrorist responsible.
Episode 20
When an attack on the village leads to Kali's kidnapping, can Sheena rescue her before she is sold into modern day slavery without become a prisoner herself?
Episode 21
Sheena and Cutter find themselves surrounded by billions of killer ants which block their every means of escape.
Episode 22
When a young girl and a government official die in a fiery car bomb, Sheena discovers a religious cult with murderous intent.
