In the dark megalopolis of Méridiana, the silhouette of a mysterious character named Cybersix emerges, having escaped her creator, Doctor Von Reichter. By day, Cybersix, who adopted the male identity of Adrian Seidelman, is a literature teacher in a local high school and, by night, she 'transforms' back into Cybersix to fight Von Reichter's abominable creations and foil his plans. Soon, she's aided by her surviving brother, now named Data 7, a black bioroid panther.
Episode 1
High school biology teacher Lucas Amato finds a tube with a glowing green ooze and takes it home with him. The next night a woman named Cybersix visits Lucas to retrieve the ooze called Sustenance. But before she has a chance to get it, a big strange man breaks into Lucas's apartment.
Episode 2
Cybersix's creator sends his bioroid black panther pet called Data 7 to kill her.
Episode 3
Jose creates a mud monster from primordial ooze which can change its shape to counter any attack and sends it after Cybersix.
Episode 4
Jose tries to hire a detective to help him capture Cybersix. When he refuses, Jose kidnaps his sister and will only return her in exchange for Cybersix.
Episode 5
Lori bumps into Jose and accidentally gets her CD switched for the CD-ROM he's using to program his tunneling robot that's going to dig into the city's treasury.
Episode 6
Jose uses one of Von Riecher's creations to control birds and have them attack the people of Maridiana.
Episode 7
Jose uses special devices to brainwash six police officers and force them to hunt down Cybersix.
Episode 8
Cybersix is attacked by goblin-like creatures that seem to fear the light.
Episode 9
After being bitten by a wolfman Lucas finds himself getting hairier and becomes fascinated by the new teacher. Cybersix resents her influence over him but she's too busy fighting the wolfwoman Dr. Von Reichter has sent to hunt her.
Episode 10
Von Riecher gifts Jose a strange egg that hatches into a soul-absorbing floating eye. Jose takes the eye to the city and soon the entire population, except for Cybersix, is soulless.
Episode 11
Jose builds a bunch of mechanical animals and starts his own circus, The Greatest Show In Meridiana. Suspicious, Cybersix goes to the circus, only to be captured.
Episode 12
While on a school fieldtrip Cybersix is attacked by a techno with the power to become invisible.
Episode 13
A living island created by Dr Von Reichter begins making its way to Meridina harbour. It is programmed to explode once it arrives because he's tired of Jose's many failures and wants to wipe the slate clean.
