Nueno Mesuke, better known as Nube, is a school teacher who does more than just teach. You see, Nube's left hand is a huge, nasty-looking demon's claw. He uses it to get rid of malicious demons, ghosts, spirits and other supernatural beings that are giving his students a hard time. Nube's left hand was normal, until one fateful day when he exorcised an extremely powerful demon from a child. He was outmatched and lost his left hand. The only way to fight it was to let it enter his body. As a result, Nube has a demonic left hand where his own hand used to be. To educate and protect — that is what Jigoku Sensei Nube does.
Episode 1
A new school term begins; Hiroshi's heart is attacked by a Yōkai, so Nube must save his life.
Episode 2
Nube, Kyoko and Hiroshi investigate a ghost that appears in the bathroom.
Episode 3
A talkative youkai makes everybody hate Miki because of her harsh rumors.
Episode 4
A Kappa tries to stop the horizontal bars being used because there's a bomb.
Episode 5
Katsuya meets a troubled boy who makes him cross the 13th step.
Episode 6
A Kitsune, Yoko Tamamo, tries to kill Hiroshi to get his skull and become human. On Nube's attempt to save Hiroshi, Nube ended topless in a blood bath after he falls in a dark warehouse and his torso, arms, and back are slashed by 4 claws.
Episode 7
Nube fights Yoko Tamamo to save Hiroshi, despite his injury and blood loss. If Nube attempted to save Hiroshi, it is Hiroshi who will save and takes care of Nube with loving hug as the latter suffers in injury and blood loss.
Episode 8
Shuichi meets Hiroshi, Kyoko, Miki and Katsuya to witness a UFO.
Episode 9
Miki gains the ability to stretch her neck and spy on her friends.
Episode 10
Akira is constantly attacked by a demon who ruins his works.
Episode 11
Nube and Yukime meet again after a long time; she tries to freeze him and take him with her to the mountains.
Episode 12
After a picnic, the school bus is attacked by a youkai.
Episode 13
Katsuya steals money from a shrine, now the sword from that temple turns into a youkai trying to kill sinful people, including Katsuya.
Episode 14
Kyoko's doppelganger flees and Nube must find it before Kyoko dies.
Episode 15
Yukime returns, but this time, with plans of live as a human, causing problems to Nube, and risking her life at the end trying to save the life of a girl trapped in a fire.
Episode 16
In an attempt to save Makoto, Nube ends up possessed by a powerful youkai making impossible for him to use his Oni no te.
Episode 17
Kyoko gets swimming lessons from the pool ghost.
Episode 18
A giant fish youkai attacks the school and Nube and Youko Tamamo allies to defeat it.
Episode 19
Nube and Yukime pursuit a demon who is killing the love pairs in Doumori.
Episode 20
Nube travels into the past trying to prevent Minako-sensei's death.
Episode 21
After Katsuya accidentally kills a fish from God's lake, God's messenger tries to kill him as a punishment.
Episode 22
Portions of a ghost appear in the photos of a trip of the 5-3 students.
Episode 23
Kyoko and Miki reflect themselves on an opposing mirrors on the school at midnight showing them olders, now each time they reflect themselves they see each time more and more older.
Episode 24
Miki use the love crow legend for spend all her time with Hiroshi, causing Kyoko to get jealous.
Episode 25
No overview available.
Episode 26
Yukime creates a baby that looks like her and Nube and they must stop Yukibe from wreaking havoc in the city.
Episode 27
Izuna has kudakitsunes that can perform almost anything. One day, an evil one is born and she needs Nube's help to stop it.
Episode 28
Miki finds a Kesalan Patharan and decides to breed them for her own use. While at the mall, she must decide whether to use them all to save Nube, Kyoko, Hiroshi, and Makoto from falling to their death.
Episode 29
Nube's class creates a haunted house for a school festival, but it gets scorned by a young gang group who always love to cause a lot of trouble to Domori's populace. Nube then decides to bring in the real spirits for their enjoyment.
Episode 30
Makoto begins to be pursued by the Ninomia Kinjirou statue after he accidentally rips an ancient book.
Episode 31
Ai Shinozaki, a great violinist at Doumori begins to have eyeballs appearing on her body because she steals. She must decide to confess or be overtaken by the demon.
Episode 32
A girl's spirit begins attacking the students of 5-3 because of a missing book that used to be her favorite.
Episode 33
Mamoru Kazama, a student of Ritsuko sensei's class is sent to the hospital after he sees a dancing demon on top of his house. Ritsuko sensei feels she must protect him and stays with him in the face of danger.
Episode 34
One day, Nube's demon hand begins to overtake his body and Tamamo, Hiroshi, and Kyoko must travel to the past to find the solution before Nube becomes an Oni.
Episode 35
Miki realizes one day that buildings are being moved after she says where she wants them. No one else notices because they are already "accustomed" to the new arrangement. She ends up wishing Domori Elementary away and it's up to her to save the school.
Episode 36
Kyoko bets with Miki that she will learn to play the piano in one week. Kyoko ends up going to secret midnight lessons thinking it's a dream. Her weariness begins to show and it concerns Miki and Nube.
Episode 37
Makoto stumbles upon a 20-year-old agenda once owned by a student who forgot everything. The student ends up drowning and the spirit comes back to help Makoto. Shortly, the spirit begins to try to kill Makoto and have him discover his body.
Episode 38
Yukime upsets Zashiki Warashi, so the Zashiki Warashi brings good luck to Nube by having Ritsuko sensei ask Nube on a date and making Yukime jealous.
Episode 39
Shuichi's turtle that went down the drain comes back as a monster that Tamamo thinks will be satisfied if Shuichi is sacrificed.
Episode 40
Izuna begins to spontaneously burst into fire at random times. She must relieve her stress that has built up or else she will perish.
Episode 41
A model of the human body in a science class inherits a spirit and doesn't realize that he isn't an human being. He wants to become friends with Nube's classmates, but they are terrified of him.
Episode 42
Hiroshi's mother is reincarnated as a 4-year-old school girl to see him, but Hiroshi doesn't believe it. She was reincarnated for Hiroshi to know the situation before she died.
Episode 43
Yukime is fooled into thinking that taking a human's soul will turn her into a human. Yukime targets Ritsuko sensei because Yukime wants to have a relationship with Nube.
Episode 44
A demon takes on the form of Nube and orders every student in the class to tell their scariest stories to aid in opening the portal to the spirit world.
Episode 45
No overview available.
Episode 46
No overview available.
Episode 47
The God of Poverty targets Nube and makes his money vanish so he becomes poor. What both of them don't realize is that everyone that knows Nube loves and cares for him.
Episode 48
Kyoko wakes up one day just to discover that she already becomes a mature woman and her life becomes entirely different than how it should be.
Episode 49
A collection/recap of all the episodes(an encyclopedia of demons, spirits, the story of the Oni no te, the romances, etc.)
